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(2016) found that curcumin pretreatment significantly restored the inhibitory effect of high glucose on the expression of Wnt5a and nuclear β-catenin protein, inhibited the increased expression reversed the increase of β-Catenin and p-GSK3βof transforming growth factor (TGF-β1) and fibronectin, and downregulated the expression of 8-OHDG

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To investigate the impact of the R671W variant, the researchers modeled it in Drosophila